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M9480840.TXT
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1994-09-05
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Document 0840
DOCN M9480840
TI Evaluation of the Murex SUDS HIV-1 antibody test in a mixed population.
DT 9410
AU Johnson JE; Ely DD; Overman SB; Goodman NL; University of Kentucky
Medical Center, Lexington.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:554 (abstract no. C-364).
Unique Identifier : AIDSLINE ASM94/94313105
AB Serum specimens from 304 patients and 116 blood donors were tested for
HIV-1 antibody using the Murex SUDS HIV-1 and the Genetic Systems LAV
EIA test systems. There were 320 specimens non-reactive with both SUDS
and LAV (116 blood donor specimens and 204 patient specimens). There
were 53 patient specimens which were reproducibly reactive by LAV and
confirmed as positive by both Western blot (WB) and immunofluorescence
(IFA). All 53 of these specimens were reactive by SUDS (100% sensitive).
Of 47 specimens reproducibly reactive by LAV but unconfirmed by WB and
IFA, the SUDS test was reactive in only 4 instances. The overall results
of this study demonstrate that SUDS was 100% sensitive (53/53) and 98.9%
specific (363/367) and indicate that the Murex SUDS HIV-1 antibody test
system may be acceptable for rapid screening in specific situations.
DE Acquired Immunodeficiency Syndrome/BLOOD/*DIAGNOSIS/PREVENTION &
CONTROL *Blood Donors Blotting, Western/METHODS Comparative Study
Fluorescent Antibody Technique Human HIV Antibodies/*BLOOD
HIV-1/*ISOLATION & PURIF Immunoenzyme Techniques Mass
Screening/METHODS Reagent Kits, Diagnostic Sensitivity and Specificity
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).